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Manetti M, Guiducci S, Romano E, Ceccarelli C, Bellando-Randone S, Conforti ML, Ibba-Manneschi L, Matucci-Cerinic M (2011) Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis

Vitamin B12 is also a vital nutrient for brain development, both during pregnancy and in early infancy

The formulation is simple to administer

This is a known consideration in freeze-dried and frozen formulation research, where excipients such as mannitol are studied specifically to protect molecules through these phase changes, as covered in the Journal of Pharmaceutical Sciences review cited above